Men's second seed Rafael Nadal starts against Israel's Dudi Sela while three-time champion Novak Djokovic faces American Tennys Sandgren.
Serena Williams edged past Spain's Garbine Muguruza 2-6, 6-3, 6-2 to reach the quarters.
Venus and Serena Williams won the US Open women's doubles crown on Monday with a dominating 6-2, 6-2 victory over top seeds Cara Black and Liezel Huber.
The past, present and future of women's tennis will all come together at the Australian Open on Thursday when Serena Williams and Justine Henin square off against Chinese opponents for a place in the final.
Serena Williams and Andy Murray had brief hiccups on the way to convincing victories at the US Open, each choosing different tactics to remain on track for a long ride into the year's final Grand Slam.
Serena Williams, who held all four of tennis's grand slam titles for the second time in her career and won 53 of 56 matches in 2015, was named Sportsperson of the Year by Sports Illustrated magazine on Monday.
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Serena Williams' decision to end a 14-year boycott of the BNP Paribas Open has been warmly welcomed by her peers with good friend and rival Caroline Wozniacki saying it was "great for tennis".
World No 1 Serena Williams overcame a wobbly start to open the defence of her Sony Open crown with a spirited 7-6(9-7), 6-2 win over Kazakhstan's Yaroslava Shvedova on Thursday.
Juan Martin del Potro suffered the first real upset and Victoria Azarenka had a big scare, but Serena Williams and Andy Murray eased through challenging ties to reach the last 16 of the Australian Open on Saturday.
"I'm drama, and I don't want to be drama," Williams said after reaching the fourth round with a ill-tempered 4-6 6-3 6-4 win over Maria Jose Martinez Sanchez.
Novak Djokovic took a first unsteady step toward completing the calendar-year Grand Slam on Tuesday as the Serb laboured into the second round of the US Open with a 6-1, 6-7(5), 6-2, 6-1 win over dashing Danish teenager Holger Rune.
World number one Serena Williams was named WTA Player of the Year for a second time at a tour ceremony on Thursday. Williams, who did not attend the event, won the US Open last year and reached the Wimbledon final. She also claimed a gold medal with sister Venus in the doubles at the Beijing Olympics. In her career, the American has claimed ten Grand Slam titles and she was also the WTA Player of the Year in 2002.
Serena Williams is leaving tennis but her love affair with the sport will continue assured the 23-times Grand Slam winner on Monday, after reaching the second round of the US Open which could be her competitive swan song.
The triumph also lifted the 26-year-old back to the summit of the world rankings for the first time since August 2003 and this time she does not want to let go.
Serena Williams admitted that a bad back sustained during practice hampered her movement during her shock fourth round loss to Ana Ivanovic on Sunday, but refused to blame the injury for her stunning exit that blew the Australian Open wide open.
Images from the Australian Open matches played on Sunday.
After feeling the full force of Garbine Muguruza's ferocious forehand and being made to scrap like a bloodied street fighter, Serena Williams has seen enough of the Spaniard to make a bold prediction -- soon she will be a Wimbledon champion too.
Serena Williams weathered an early challenge from Russian Vera Zvonareva before the former World No 2 crumbled to lose 7-5, 6-0 in the second round of the Australian Open on Thursday.
Serena Williams won her 750th career match to stay on track for her ninth Miami Open title when she beat Zarina Diyas of Kazakhstan 7-5 6-3 in the third round in Florida on Saturday. The world number one improved her career record to 750-125, seventh on the all-time list and just three match wins behind Lindsay Davenport's 753. Martina Navratilova sits atop the all-time list with 1,442 wins. The 34-year-old Williams will meet Russian Svetlana Kuznetsova in the fourth round. The 15th seed defeated France's Caroline Garcia 4-6 6-2 7-6(6). Unlike the last time they met, when Williams required 54 minutes and Diyas won just two games, the 22-year-old Kazak gave the American some trouble in the heat and humidity of Miami.
Former champion Serena Williams shocked the French Open crowd, and herself, by losing to Virginie Razzano in the first round on Tuesday, her earliest exit from a grand slam in the 47 appearances she has made in an outstanding career.
The ruthless American needed less than an hour to defeat Sharapova 6-1, 6-1 and notch her 19th consecutive win over the Russian in what some charitably dub a "rivalry."
Defending champion Serena Williams finished her last US Open tune-up in style by beating Romanian third seed Simona Halep 6-3, 7-6(5) to win the Western & Southern Open on Sunday.
World No 1 Serena Williams comfortably beat 15-year-old CiCi Bellis.
India's teen tennis sensation said it was good to know that she could match the six-time Grand Slam champion.
The imposter who did turn up got dragged into a two hour 11 minute tussle in which she failed to convert 11 of the 12 break points that fell her way.
The Cincinnati Open claimed two more high-profile victims on Thursday with Grand Slam champions Li Na and Petra Kvitova crashing out, while Russian pair Maria Sharapova and Vera Zvonareva crunched their opponents en route to the quarter-finals.
Australia's Hewitt earned the accolade for the second year running, while American Williams was honoured for the first time.
Serena Williams again showed the gaping chasm between her and the rest of the field when she retained her Wimbledon singles crown with a crushing 6-3, 6-2 win over Russia's Vera Zvonareva on Saturday.
A summary of sports events and sportspersons, who made news on Tuesday.
World number one Serena Williams was battered into a 4-6, 6-2, 6-3 submission by a fired-up Nadia Petrova in the third round of the Madrid Open on Wednesday.
Images from Day 3 of the Australian Open in Melbourne on Wednesday
Spanish fourth seed Garbine Muguruza claimed her maiden Grand Slam title when she beat World No 1 and defending champion Serena Williams 7-5, 6-4 in the French Open final on Saturday.
Serena Williams, Simone Biles and Ted Ligety were among the finalists for United States Olympic Committee (USOC) male and female athletes of year honours announced on Thursday.
A despondent Serena Williams grudgingly faced reporters after her 7-6 6-1 defeat to top seed Justine Henin in Tuesday's quarter-finals of the U.S. Open, tears staining her cheeks after the bitter result.
Top ranked Serena Williams made a successful return to hard courts with a 6-3, 6-2 thrashing of former French Open champion Francesca Schiavone in the second round of the Rogers Cup on Wednesday.
World No 1 Serena Williams has tormented Maria Sharapova for over a decade
The world number two said her near-misses initially left her deflated and sick of tennis, but she was now over the pain.
Venus Williams, inspired by the sight of younger sister Serena earlier in the week, stepped back onto the court alongside Jamie Murray in the mixed doubles thanks to a wildcard entry and promptly booked a spot in the second round.
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